The development of heat exchangers has a long history. It is understood that in the early 1930s, Sweden first made spiral plate heat exchangers. Next, a plate-fin heat exchanger made of copper and its alloy materials was manufactured by the UK by brazing, which was used to dissipate heat from aircraft engines. In the late 1930s, Sweden produced the first plate and shell heat exchanger for a pulp mill. Around the 1960s, due to the rapid development of space technology and cutting-edge science, various high-efficiency compact coolers were urgently needed, coupled with the development of stamping, brazing and sealing technologies, the heat exchanger manufacturing process was further improved, and Promote the vigorous development and wide application of compact plate surface heat exchangers. In addition, since the 1960s, in order to meet the needs of heat exchange and energy saving under high temperature and high pressure conditions, typical shell and tube heat exchangers have also been further developed.
Dynamic dividing line
At present, there are many types of heat exchangers on the Chinese market. If they are classified according to the shape and structure of their heat transfer surfaces, they can be divided into tube, plate and other types of heat exchangers. Among them, the tube heat exchanger can be divided into shell and tube heat exchangers, sleeve heat exchangers, coiled tube heat exchangers; plate heat exchangers can be divided into plate heat exchangers, plate fin heat exchangers, Plate and shell heat exchanger, spiral plate heat exchanger.
管 In China's pharmaceutical industry, tube and shell heat exchangers have always dominated production and use due to their sturdy structure, high reliability, and strong adaptability. They have been widely used by pharmaceutical companies.
Stern tube and shell heat exchangers are also called tandem tube heat exchangers. It is a partition heat exchanger with the wall surface of the tube bundle enclosed in the shell as the heat transfer surface. This heat exchanger has a simple structure and reliable operation. It can be manufactured with various structural materials (mainly metal materials), can be used under high temperature and high pressure, and is the most widely used type at present.
New Year cruise line dividing line
In recent years, all walks of life have required energy conservation and environmental protection. The demand for heat exchangers in the pharmaceutical industry is also increasing, and ordinary low-efficiency heat exchangers will be eliminated. China's heat exchanger industry will usher in opportunities and challenges in the future. According to experts' estimates, the compound growth rate of China's heat exchanger industry will be 11% from 2015 to 2020, corresponding to 77 billion yuan and 130 billion yuan of China's heat exchanger market size in 2015 and 2020 respectively.
But from the current situation of the development of China's heat exchanger industry, there are still many problems. The development of products, the supply of upstream raw materials, and the lack of production equipment have resulted in a low manufacturing process. In the context of the continuous development of the pharmaceutical industry, China's shell and tube heat exchanger companies also urgently need to improve the manufacturing process,
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The heat exchanger needs to be improved
The new version of China's GMP regulations stipulates: "The design, selection, installation, modification and maintenance of equipment must meet the intended use, and the risk of pollution, cross-contamination, confusion and error should be minimized to facilitate operation, cleaning, maintenance and when necessary, Disinfection or sterilization. " This regulation not only raises the requirements for equipment in the pharmaceutical system, but is also the basic condition for the selection of heat exchangers in the pharmaceutical water system.
Heat exchangers play an important role in the production process of many industries, and in the biopharmaceutical industry, they are indispensable equipment in the production process, and have higher sanitary requirements, because heat exchangers are important in the process of water for injection Parts, many processes need to be heat-exchanged by the heat exchanger before proceeding to the next process, so the selection of the heat exchanger is very important. The new version of GMP recommends that double-tube-sheet shell-and-tube heat exchangers should be used for pharmaceutical water processes.
Iger has designed a series of sterile double tube-sheet shell-and-tube heat exchangers for different process requirements in pharmaceutical water systems. The heat exchangers produced by Iger in the early stage are more suitable for each use point of water for injection, used for low-temperature liquid distribution and cleaning (Figure 1), and less used on the main pipeline with a large flow. In recent years, with the launch of domestic monoclonal antibody preparation projects, Iger has specially designed a series of large-sized heat exchangers for the process requirements of these projects. The maximum length is only about 1 m, which can better solve the main pipeline system. Some process conditions.